S-(+)-Pentedrone and R-(+)-methylone as the most oxidative and cytotoxic enantiomers to dopaminergic SH-SY5Y cells: Role of MRP1 and P-gp in cathinones enantioselectivity
Bárbara Silva, Andreia Palmeira, Renata Silva, Carla Fernandes, Paula Guedes de Pinho, Fernando Remião
Topics & Concepts
ChemistryEnantiomerPharmacologyCathinoneCytotoxicitySH-SY5YGlutathioneOxidative stressEffluxStereochemistryBiochemistryIn vitroCell cultureEnzymeDopamineBiologyInternal medicineMedicineGeneticsNeuroblastomaAmphetamineForensic Toxicology and Drug AnalysisDrug Transport and Resistance MechanismsInflammatory mediators and NSAID effects