Photo-induced tandem cyclization of unsaturated amides with thiocyanates to access thiocyanated heterocycles
Yanzhao Zeng, Qinqin Yan, Lijun Tu, Zihang Zhang, Lijun Li, Zejiang Li
Abstract
-acryloyl aldehyde hydrazones/unsaturated coumarins with thiocyanate were completed, efficiently producing diverse thiocyanated pyrazolones/polycyclic coumarins with good selectivity. Meanwhile, various control experiments (scaled-up operations, substituent transformations, and radical capture/light-on-off operations) explored the merits and the plausible cyclization process of the thiocyanation systems.
Topics & Concepts
ChemistryTandemSubstituentAldehydeRadical cyclizationThiocyanateCombinatorial chemistryYield (engineering)Reaction conditionsOrganic chemistryAmmonium thiocyanateMedicinal chemistryCoumarinProcess (computing)Cascade reactionContext (archaeology)ThiocarbamatesRadicalSodium thiocyanateSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsChemical Synthesis and Reactions