Visible-Light-Induced Copper-Catalyzed Intermolecular Three-Component Difluoroalkyl Thiocyanidation of Alkenes
Zhaoming Hu, Yanzhao Wang, Kaiji Wang, Jingjing Wu, Fanhong Wu
Abstract
In this report, we develop a new strategy for visible-light-induced, copper-catalyzed three-component difluoroalkyl thiocyanidation of alkenes to construct a series of important difluorothiocyanate compounds. The new approach can also be applied to perfluorothiocyanate compounds, even target molecules containing drug/natural product skeletons. Mechanistic studies provide that the copper complex plays a dual role, as both the photoredox catalyst for electron transfer and the cross-coupling catalyst for C-SCN bond formation.
Topics & Concepts
ChemistryCopperCatalysisIntermolecular forceComponent (thermodynamics)MoleculeCombinatorial chemistryVisible spectrumPhotochemistryElectron transferOrganic chemistryPhysicsOptoelectronicsThermodynamicsFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesRadical Photochemical Reactions