m<sup>6</sup>A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2
Wei Wang, Ying He, Lulu Zhai, Long-Jiang Chen, Lichao Yao, Lun Wu, Zhi‐Gang Tang, Jinzhuo Ning
Abstract
A demethylase, plays a critical role in promoting PC growth, migration and invasion, suggesting that FTO may be a potential therapeutic target for treating PC.
Topics & Concepts
DemethylaseBiologyGene knockdownMessenger RNARNACancer researchIn vitroSmall interfering RNAPancreatic cancerCell biologyCancerGeneBiochemistryHistoneGeneticsRNA modifications and cancerCancer-related gene regulationEpigenetics and DNA Methylation