Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes
Arthur Bassot, Carina Prip‐Buus, Anaïs Alves, Olivier Berdeaux, Johan Perrier, Véronique Lenoir, J. Cao, Marie-Agnès Berger, Emmanuelle Loizon, Stéphanie Cabaret, Baptiste Panthu, Jennifer Rieusset, Béatrice Morio
Topics & Concepts
MFN2Gene silencingTriglycerideFatty liverCell biologymitochondrial fusionLipid metabolismChemistryMitochondrionFatty acidBiologyBiochemistryInternal medicineCholesterolMedicineGeneDiseaseMitochondrial DNAMitochondrial Function and PathologyEndoplasmic Reticulum Stress and DiseaseLipid metabolism and biosynthesis