Toxicological profile of calcium carbonate nanoparticles for industrial applications
Marta d’Amora, Freddy Liendo, Fabio Alessandro Deorsola, Samir Bensaid, Silvia Giordani
Abstract
Calcium carbonate nanoparticles (CaCO3NPs) derived from CO2 are promising materials for different industrial applications. It is imperative to understand their toxicological profile in biological systems as the human and environmental exposures to CaCO3NPs increases with growing production. Here, we analyse the cytotoxicity of CaCO3NPs synthesized from a CaO slurry on two cell lines, and in vivo on zebrafish (Danio Rerio). Our results demonstrate the CaCO3NPs in vitro safety as they do not cause cell death or genotoxicity. Moreover, zebrafish treated with CaCO3NPs develop without any abnormalities, confirming the safety and biocompatibility of this nanomaterial.