Design and Synthesis of Fluoro‐containing Hypervalent Iodane (III) Reagents for Visible‐light‐triggered Cyclization of Alkynoates to 3‐Fluoroalkylated Coumarins
Ningning Zhou, Kun Wang, Tingting Zhao, Ruiyue Liu, Mingyang Rui, Xia Zhao, Jiaxu Feng, Kui Lu
Abstract
Abstract A series of novel fluoro‐containing hypervalent iodane (III) reagents was designed and synthesized. By employing these novel hypervalent iodane (III) reagents, an efficient visible‐light‐triggered radical cyclization of alkynoates to diversely 3‐fluoroalkylated coumarins was developed under metal free condition. It provided an alternative and environmental friendly approach for the installation of 3‐fluoroalkyl motif into synthetically valuable building block coumarins.
Topics & Concepts
Hypervalent moleculeReagentChemistryCombinatorial chemistryVisible spectrumOrganic chemistryOptoelectronicsPhysicsOxidative Organic Chemistry ReactionsRadical Photochemical ReactionsFluorine in Organic Chemistry