Macrophage Mitochondrial Biogenesis and Metabolic Reprogramming Induced by Leishmania donovani Require Lipophosphoglycan and Type I Interferon Signaling
Hamlet Acevedo Ospina, Marie-Michèle Guay-Vincent, Albert Descoteaux
Abstract
To colonize host phagocytes, Leishmania metacyclic promastigotes subvert host defense mechanisms and create a specialized intracellular niche adapted to their replication. This is accomplished through the action of virulence factors, including the surface coat glycoconjugate lipophosphoglycan.
Topics & Concepts
LipophosphoglycanBiologyCell biologyLeishmania donovaniMitochondrial biogenesisLeishmaniaSignal transductionBiogenesisMitochondrionBiochemistryImmunologyWorld Wide WebGeneVisceral leishmaniasisLeishmaniasisParasite hostingComputer scienceResearch on Leishmaniasis StudiesTrypanosoma species research and implicationsParasites and Host Interactions