High-fat diet activates liver iPLA2γ generating eicosanoids that mediate metabolic stress
Sung Ho Moon, Beverly Gibson Dilthey, Xinping Liu, Shaoping Guan, Harold F. Sims, Richard W. Gross
Abstract
γ-mediated hepatic 12-HETE production leading to mitochondrial dysfunction and hepatic cell death.
Topics & Concepts
EndocrinologyInternal medicineMitochondrial permeability transition poreInsulin resistanceHepatocyteLipotoxicityBioenergeticsMitochondrionMitochondrial ROSEicosanoidLiver injuryBiologyCalciumChemistryProgrammed cell deathOxidative stressArachidonic acidInsulinBiochemistryMedicineEnzymeApoptosisIn vitroLiver Disease Diagnosis and TreatmentPeroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism