Blood volume expansion, normovolemia, and clinical outcomes in chronic human heart failure: more is better
Wayne L. Miller, John E. Strobeck, Diane E. Grill, Brian P. Mullan
Abstract
The novel findings of this study demonstrate that intravascular volume profiles among the patients with chronic heart failure (HF) vary substantially even with similar clinical compensation. Importantly, a profile of blood volume (BV) expansion (compared with a normal BV) is associated with lower HF mortality/morbidity. Furthermore, RBC polycythemia is common and independently associated with improved outcomes. These observations support BV expansion with RBC polycythemia as a compensatory mechanism in chronic HF.
Topics & Concepts
MedicineInternal medicineCohortHeart failureCardiologyProspective cohort studyCohort studyHeart Failure Treatment and ManagementDialysis and Renal Disease ManagementHemodynamic Monitoring and Therapy