GTW inhibits the Epithelial to Mesenchymal Transition of Epithelial Ovarian Cancer via ILK/AKT/GSK3β/Slug Signalling Pathway
Ying Feng, Fuyin Le, Puyuan Tian, Yanying Zhong, Fuliang Zhan, Genhua Huang, Hui Hu, Tingtao Chen, Buzhen Tan
Abstract
Background: Epithelial ovarian cancer (EOC) accounts for the most lethal of all gynaecological cancers which is attributed to metastasis, invasiveness and drug resistance. A crucial link has been found between epithelial-mesenchymal transition (EMT) and cancer metastasis and chemo-resistance. Previous studies have confirmed that one of the main components of tripterygium glycosides (GTW)-triptolide (TPL) has anticancer effects.
Topics & Concepts
SlugProtein kinase BEpithelial–mesenchymal transitionCancer researchGSK-3MetastasisIntegrin-linked kinaseGSK3BCisplatinPI3K/AKT/mTOR pathwayChemistryKinaseMedicineCancerBiologySignal transductionInternal medicineCell biologyCell cycleChemotherapyCyclin-dependent kinase 2Cancer Mechanisms and TherapyNatural Compounds in Disease TreatmentCancer-related molecular mechanisms research