PET Imaging for Dynamically Monitoring Neuroinflammation in APP/PS1 Mouse Model Using [18F]DPA714
Wei Hu, Donghui Pan, Yalin Wang, Weiqi Bao, Chuantao Zuo, Yihui Guan, Fengchun Hua, Min Yang, Jun Zhao
Abstract
Background: In the pathogenesis of Alzheimer's diseases, microglia plays an increasing important role. Especially, molecular imaging of neuroinflammatory targeting microglia activation and high expression of 18-kDa translocator protein is a hot research focus in recent years. Dynamically monitor neuroinflammation is crucial for discovering the best time point of antiinflammatory therapy. Motivated by this, PET imaging in a APP/PS1 mouse model of Alzheimer's Diseases using 18F-labeled DPA-714 to monitor microglia activation and neuroinflammation are performed in this paper.
Topics & Concepts
Translocator proteinNeuroinflammationMicrogliaHippocampusPositron emission tomographyMagnetic resonance imagingPathologyChemistryNeurosciencePathogenesisMedicinePsychologyInternal medicineInflammationDiseaseRadiologyNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsImmune cells in cancer