Harnessing the power of α-diazo compounds: emerging strategies and expanding applications
Mumtaz Ahmad, Anuj Kumar, Shakir Ahamad, Kishor Mohanan
Abstract
generation protocols has addressed safety concerns, making highly reactive diazo species such as trifluorodiazoethane and diazoacetonitrile more accessible. Their increasing significance in pharmaceutical and materials science stems from their crucial role in synthesizing fluorinated and cyano-functionalized scaffolds. These reagents facilitate the construction of diverse heterocyclic frameworks, including three-, four-, five-, six-, and seven-membered rings, as well as small carbocycles and fused heterocycles. Additionally, multicomponent reactions (MCRs) involving diazo compounds have emerged as a powerful strategy for synthesizing complex molecular scaffolds efficiently and sustainably. This review explores recent advances in α-diazo chemistry, focusing on new applications in organic synthesis and future research directions.