Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE2, TNF-α, IL-6 and histopathological study
Madlen B. Labib, Ahmed M. Fayez, El‐Shaymaa El‐Nahass, Mayada Ragab Farag Awadallah, Peter A. Halim
Topics & Concepts
CelecoxibChemistryPharmacologyTetrazoleIn vivoCyclooxygenaseAnti-inflammatoryEdemaStereochemistryEnzymeBiochemistryMedicineInternal medicineBiologyBiotechnologyInflammatory mediators and NSAID effectsSynthesis of β-Lactam CompoundsSynthesis and biological activity