Recent advances in directed sp<sup>2</sup> C–H functionalization towards the synthesis of N-heterocycles and O-heterocycles
Bhargav Desai, Monak Patel, Bharatkumar Z. Dholakiya, Sujoy Rana, Togati Naveen
Abstract
Heterocyclic compounds are widely present in the core structures of several natural products, pharmaceuticals and agrochemicals, and thus great efforts have been devoted to their synthesis in a mild and simpler way. In the past decade, remarkable progress has been made in the field of heterocycle synthesis by employing C-H functionalization as an emerging synthetic strategy. As a complement to previous protocols, transition metal catalyzed C-H functionalization of arenes using various directing groups has recently emerged as a powerful tool to create different classes of heterocycles. This review is mainly focussed on the recent key progress made in the field of the synthesis of N,O-heterocycles from olefins and allenes by using nitrogen based and oxidizing directing groups.