RETRACTED: Oncogenic miR-27a delivered by exosomes binds to SFRP1 and promotes angiogenesis in renal clear cell carcinoma
Yi Hou, Fan Li, Hai Li
Abstract
experiments substantiated that miR-27a-loaded exosomes from RCCC cells repressed SFRP1, augmenting the viability, migration, and angiogenesis of RCCC cells. Together, RCCC-derived miR-27a-loaded exosomes inhibit SFRP1 expression and accelerate tumor angiogenesis in RCCC.
Topics & Concepts
AngiogenesisMicrovesiclesmicroRNACancer researchMatrigelLuciferaseIn vivoExosomeBiologyCell biologyTransfectionCell cultureGeneBiotechnologyGeneticsBiochemistryExtracellular vesicles in diseaseMicroRNA in disease regulationCircular RNAs in diseases