Discovery of penipanoid C-inspired 2-(3,4,5-trimethoxybenzoyl)quinazolin-4(3H)-one derivatives as potential anticancer agents by inhibiting cell proliferation and inducing apoptosis in hepatocellular carcinoma cells
Chaojie Wang, Xinxin Guo, Rui-Qin Zhai, Changning Sun, Guokai Xiao, Jin Chen, Mei‐Yan Wei, Chang‐Lun Shao, Yuchao Gu
Topics & Concepts
SorafenibApoptosisChemistryHepatocellular carcinomaLiver cancerCancer researchCell cultureCytotoxic T cellCell growthIn vivoCancer cellProgrammed cell deathCytotoxicityCell cycleCancerCell cycle checkpointPharmacologyIn vitroBiochemistryBiologyInternal medicineMedicineBiotechnologyGeneticsQuinazolinone synthesis and applicationsCancer Mechanisms and TherapySynthesis and biological activity