Comparison of Iron Oxide Nanoparticles in Photothermia and Magnetic Hyperthermia: Effects of Clustering and Silica Encapsulation on Nanoparticles’ Heating Yield
Sebastjan Nemec, Slavko Kralj, Claire Wilhelm, Ali Abou‐Hassan, Marie‐Pierre Rols, Jelena Kolosnjaj‐Tabi
Abstract
Photothermal therapy is gathering momentum. In order to assess the effects of the encapsulation of individual or clustered superparamagnetic iron oxide nanoparticles (SPIONs) on nanoparticle light-to-heat conversion, we designed and tested individual and clustered SPIONs encapsulated within a silica shell. Our study compared both photothermia and magnetic hyperthermia, and it involved individual SPIONs as well as silica-encapsulated individual and clustered SPIONs. While, as expected, SPION clustering reduced heat generation in magnetic hyperthermia, the silica shell improved SPION heating in photothermia.
Topics & Concepts
NanoparticleMaterials scienceIron oxide nanoparticlesMagnetic nanoparticlesNanotechnologyHyperthermiaChemical engineeringMedicineEngineeringInternal medicineNanoparticle-Based Drug DeliveryNanofluid Flow and Heat TransferPhotoacoustic and Ultrasonic Imaging