Base-mediated cascade amidination/<i>N</i>-alkylation of amines by alcohols
Chunyan Zhang, Zuyu Liang, Fenghong Lu, Xiaofei Jia, Guoying Zhang, Mao‐Lin Hu
Abstract
N labeled amine and could be scaled up to 1 mol scale offering 138.7 g of the desired product in good yield in one-pot. Mechanistic studies provided strong evidence for the amidination of amines with nitriles facilitated by t-BuOK.
Topics & Concepts
AlkylationCascadeBase (topology)ChemistryCombinatorial chemistryOrganic chemistryCatalysisChromatographyMathematicsMathematical analysisChemical Synthesis and AnalysisAsymmetric Hydrogenation and CatalysisChemical Synthesis and Reactions