Cationic-motif-modified exosomes for mRNA delivery to retinal photoreceptors
Héctor A. Millán Cotto, Tanvi Vinod Pathrikar, Bill Hakim, Helna Mary Baby, Hengli Zhang, Peng Zhao, Ronak Ansaripour, Rouzbeh Amini, Rebecca L. Carrier, Ambika G. Bajpayee
Abstract
Cationic-motif-modified exosomes provide a platform for gene delivery by overcoming ocular barriers faced during topical delivery as they exhibit full-depth penetration in porcine retinal explants significantly higher than native exosomes.
Topics & Concepts
MicrovesiclesGene deliveryRetinalCell biologyMessenger RNACationic polymerizationDelivery systemChemistryPenetration (warfare)microRNAGenetic enhancementBiologyGeneBiochemistryPharmacologyEngineeringOrganic chemistryOperations researchRNA Interference and Gene DeliveryExtracellular vesicles in diseaseCorneal Surgery and Treatments