Cobalt-catalyzed Divergent Markovnikov and Anti-Markovnikov Hydroamination
Xianggui Zhang, Zixin He, Peng Guo, Zheng Chen, Ke‐Yin Ye
Abstract
Catalytic hydroamination of the readily available alkenes is among the most straightforward means to construct diverse alkyl amines. To this end, the facile access to both regioselectivity, i.e., Markovnikov or anti-Markovnikov hydroamination, with minimum reaction-parameter alternation, remains challenging. Herein, we report a cobalt-catalyzed highly selective and divergent Markovnikov and anti-Markovnikov hydroamination of alkenes, in which the switch of regioselectivity is achieved simply by the variation of the addition sequence of 9-BBN.
Topics & Concepts
Markovnikov's ruleHydroaminationChemistryRegioselectivityCatalysisCombinatorial chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesRadical Photochemical Reactions