Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment
Hridesh Banerjee, Hector Nieves-Rosado, Aditi Kulkarni, Benjamin Murter, Kyle McGrath, Uma Chandran, Alexander Chang, Andrea L. Szymczak-Workman, Lazar Vujanović, Greg M. Delgoffe, Robert L. Ferris, Larry Kane
Abstract
Treg cells may be a relevant therapeutic target cell type for the treatment of cancer.
Topics & Concepts
PhenotypeTreg cellBiologyTumor microenvironmentImmunologyCell biologyLymphatic systemCancer researchImmune systemT cellGeneGeneticsIL-2 receptorGalectins and Cancer BiologySignaling Pathways in DiseaseToxin Mechanisms and Immunotoxins