Exosome biogenesis, secretion and function of exosomal miRNAs in skeletal muscle myogenesis
Binglin Yue, Haiyan Yang, Jian Wang, Wenxiu Ru, Jiyao Wu, Yongzhen Huang, Xianyong Lan, Chuzhao Lei, Hong Chen
Abstract
Exosomes are membrane-bound extracellular vesicles that are produced in the endosomal compartment of most mammalian cell types and then released. Exosomes are effective carriers for the intercellular material transfer of material that can influence a series of physiological and pathological processes in recipient cells. Among loaded cargoes, non-coding RNAs (ncRNAs) vary for the exosome-producing cell and its homeostatic state, and characterization of the biogenesis and secretion of exosomal ncRNAs and the functions of these ncRNAs in skeletal muscle myogenesis remain preliminary. In this review, we will describe what is currently known of exosome biogenesis, release and uptake of exosomal ncRNAs, as well as the varied functions of exosomal miRNAs in skeletal muscle myogenesis.