Complex Genomic Rearrangements following Selection in a Glutamine-Limited Medium over Hundreds of Generations
Pieter Spealman, Grace Avecilla, Julia Matthews, Ina Suresh, David Gresham
Abstract
Large-scale genomic changes, including copy number variations (CNVs), are frequently observed in long-term evolution experiments (LTEEs). We have previously reported the detection of recurrent CNVs in Saccharomyces cerevisiae populations adapting to glutamine-limited conditions over hundreds of generations. Here, we present the whole-genome sequencing (WGS) assemblies of 7 LTEE strains and their ancestor.
Topics & Concepts
BiologyGeneticsGenomeWhole genome sequencingSaccharomyces cerevisiaeSelection (genetic algorithm)Copy-number variationComputational biologyEvolutionary biologyGeneComputer scienceArtificial intelligenceChromosomal and Genetic VariationsGenomics and Phylogenetic StudiesFungal and yeast genetics research