The bidirectional relationship between CFTR and lipids
Kirsten A. Cottrill, Carlos M. Farinha, Nael A. McCarty
Abstract
Cystic Fibrosis (CF) is the most common life-shortening genetic disease among Caucasians, resulting from mutations in the gene encoding the Cystic Fibrosis Transmembrane conductance Regulator (CFTR). While work to understand this protein has resulted in new treatment strategies, it is important to emphasize that CFTR exists within a complex lipid bilayer - a concept largely overlooked when performing structural and functional studies. In this review we discuss cellular lipid imbalances in CF, mechanisms by which lipids affect membrane protein activity, and the specific impact of detergents and lipids on CFTR function.
Topics & Concepts
Cystic fibrosisCystic fibrosis transmembrane conductance regulatorTransmembrane proteinRegulatorCell biologyFunction (biology)Lipid bilayerMutationGeneBiologyChemistryBiochemistryGeneticsMembraneReceptorCystic Fibrosis Research AdvancesNeonatal Respiratory Health ResearchLegume Nitrogen Fixing Symbiosis