Utility of novel 2-furanones in synthesis of other heterocyclic compounds having anti-inflammatory activity with dual COX2/LOX inhibition
Rania H. Abd El‐Hameed, Shahenda Mahgoub, Hend Medhat El-Shanbaky, Mosaad S. Mohamed, Sahar A. Ali
Abstract
) being the most promising anti-inflammatory agents with dual COX-2/15-LOX inhibition activities along with high TNF-α inhibition activity.
Topics & Concepts
ChemistryEnzymeAnti-inflammatoryCyclooxygenaseLipoxygenaseInflammationIn vitroArachidonate 5-lipoxygenaseTumor necrosis factor alphaBiochemistryPharmacologyChemokineStereochemistryMedicineImmunologyReceptorArachidonic acidInflammatory mediators and NSAID effectsSynthesis and biological activitySynthesis and Reactions of Organic Compounds