Directing Drugs to Bugs: Antibiotic-Carbohydrate Conjugates Targeting Biofilm-Associated Lectins of <i>Pseudomonas aeruginosa</i>
Joscha Meiers, Eva Zahorska, Teresa Röhrig, Dirk Hauck, Stefanie Wagner, Alexander Titz
Abstract
, reduced the antibiotic's cytotoxicity, but also reduced its antibiotic activity against planktonic cells due to a reduced cell permeability and on target activity. This work defines the starting point for new biofilm/lectin-targeted drugs to modulate antibiotic properties and ultimately break antimicrobial resistance.
Topics & Concepts
BiofilmPseudomonas aeruginosaCiprofloxacinMicrobiologyAntimicrobialChemistryAntibioticsAntibiotic resistanceCytotoxicityDrug resistanceIn vitroBacteriaBiochemistryBiologyGeneticsBacterial biofilms and quorum sensingAntimicrobial Peptides and ActivitiesBacteriophages and microbial interactions