pH-Responsive, Adorned Nanoniosomes for Codelivery of Cisplatin and Epirubicin: Synergistic Treatment of Breast Cancer
Ali Moammeri, Koorosh Abbaspour, Alireza Zafarian, Elham Jamshidifar, Hamidreza Motasadizadeh, Farnaz Dabbagh Moghaddam, Zeinab Salehi, Pooyan Makvandi, Rassoul Dinarvand
Abstract
genes was downregulated. Histopathology results showed a reduction in the mitosis index, invasion, and pleomorphism in BALB/c inbred mice with NCE and FPNCE treatment. In this paper, for the first time, we report a niosomal nanocarrier functionalized with PEG and FA for codelivery of CIS and EPI to treat breast cancer. The results demonstrated that the codelivery of CIS and EPI through FA-PEGylated niosomes holds great potential for breast cancer treatment.
Topics & Concepts
SKBR3NanocarriersBreast cancerNiosomeApoptosisPharmacologyIn vivoChemistryCancer researchEpirubicinCisplatinCancerMedicineChemotherapyBiologyBiochemistryDrugInternal medicineBiotechnologyVesicleHuman breastMembraneNanoparticle-Based Drug DeliveryAdvancements in Transdermal Drug DeliveryDendrimers and Hyperbranched Polymers