A microphysiological early metastatic niche on a chip reveals how heterotypic cell interactions and inhibition of integrin subunit β<sub>3</sub> impact breast cancer cell extravasation
Martina Crippa, Simone Bersini, Mara Gilardi, Chiara Arrigoni, Sara Gamba, Anna Falanga, Christian Candrian, Gabriele Dubini, Marco Vanoni, Matteo Moretti
Abstract
Our microfluidic model of early metastatic niche reproduced the extravasation of breast cancer cells in presence of immune blood cells and allowed us to test the effect of an already approved inhibitor of integrin β<sub>3</sub> on cancer cell extravasation.
Topics & Concepts
ExtravasationMetastatic breast cancerBreast cancerNicheCancer cellIntegrinImmune systemCellMetastasisCancer researchProtein subunitCirculating tumor cellCancerMedicineBiologyImmunologyInternal medicineBiochemistryGeneCancer Cells and Metastasis3D Printing in Biomedical ResearchMicrofluidic and Bio-sensing Technologies