Quinoa bran insoluble dietary fiber-zinc chelate mediates intestinal flora structure to regulate glucose and lipid metabolism in obese rats
Yunfei Ge, Chunhong Wei, Uthamapriya Rajavel Arumugam, Yunjiao Wu, Longkui Cao
Abstract
Insoluble dietary fiber (IDF) and ZnSO4·7H2O were chelated to obtain the IDF-Zn. The Zn ion content was as high as 31.25 mg/g, which is a good source of Zn-rich products. The effects of IDF-Zn on metabolism and blood lipid levels were investigated in obese rats. Results showed that compared to IDF and organic Zn (ZnSO4·7H2O), IDF-Zn can significantly reduce the body weight, the levels of total cholesterol, triglycerides, and low-density lipoprotein cholesterol in serum, improve liver abnormal lipid sedimentation, oxidation stress state, and enhance the immunity of obese rats. Through 16S rRNA results, IDF-Zn intervention decreased the ratio of Firmicutes/Bacteroidetes and increased the abundance of probiotics (such as Lactobacillus, Muribaculaceae, and Bacteroides), and decreased the abundance of cellulolytic bacteria (such as Romboutsia and Clostridia-UCG-014). These results suggest that IDF-Zn can adjust intestinal flora structure of high-fat diet rats, promote liver health, reduce lipid deposits, and ultimately positively impact glucolipid metabolism.