Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths
Luke B. Roberts, Corinna Schnoeller, Rita Berkachy, Matthew Darby, Jamie Pillaye, Menno J. Oudhoff, N. Parmar, Claire Mackowiak, Delphine Sedda, Valérie Quesniaux, Bernhard Ryffel, Vaux Rachel, Kleoniki Gounaris, Sylvie Berrard, David R. Withers, William Horsnell, Murray E. Selkirk
Abstract
infection. These data demonstrate a functional role for ILC2-derived ACh in the expansion of ILC2s for maximal induction of type 2 immunity.
Topics & Concepts
Innate lymphoid cellInnate immune systemImmunologyBiologyImmunityImmune systemAcetylcholineLymphatic systemHelminthsLymphopoiesisCell biologyEndocrinologyStem cellHaematopoiesisIL-33, ST2, and ILC PathwaysEosinophilic Esophagitis