Use of a Genomic Classifier in Patients with Interstitial Lung Disease: A Systematic Review
Fayez Kheir, Juan Pablo Uribe Becerra, Brittany Bissell, Marya Ghazipura, Derrick Herman, Stephanie M Hon, Tanzib Hossain, Yet H. Khor, Shandra L. Knight, Michael Kreuter, Madalina Macrea, Manoj J Mammen, Fernando J. Martinez, Venerino Poletti, Lauren Troy, Ganesh Raghu, Kevin C Wilson
Abstract
Genomic classifier testing predicts histopathologic UIP in patients with ILD with a specificity of 92% and improves diagnostic confidence; however, sensitivity is only 68%, and testing is not widely available.
Topics & Concepts
MedicineConcordanceUsual interstitial pneumoniaConfidence intervalIdiopathic pulmonary fibrosisInterstitial lung diseaseLungClassifier (UML)PathologyRadiologyGrading (engineering)Internal medicineMeta-analysisCohortMedical diagnosisPulmonary fibrosisConcordance correlation coefficientIdiopathic interstitial pneumoniaRetrospective cohort studyHypersensitivity pneumonitisPredictive value of testsInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisLung Cancer Treatments and MutationsGenetic Associations and Epidemiology