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Neutrophil-Airway Epithelial Interactions Result in Increased Epithelial Damage and Viral Clearance during Respiratory Syncytial Virus Infection

Yu Deng, Jenny Herbert, Elisabeth Robinson, Ren Luo, Rosalind L. Smyth, Claire M. Smith

2020Journal of Virology53 citationsDOIOpen Access PDF

Abstract

This study shows that the RSV-infected human airway drives changes in the behavior of human neutrophils, including increasing activation markers and delaying apoptosis, that result in greater airway damage and viral clearance.

Topics & Concepts

BiologyRespiratory systemVirusAirwayVirologyImmunologyRespiratory epitheliumApoptosisEpitheliumViral replicationViral sheddingMedicineSurgeryAnatomyBiochemistryGeneticsRespiratory viral infections researchNeonatal Respiratory Health ResearchPneumonia and Respiratory Infections
Neutrophil-Airway Epithelial Interactions Result in Increased Epithelial Damage and Viral Clearance during Respiratory Syncytial Virus Infection | Litcius