SNHG17 enhances the malignant characteristics of tongue squamous cell carcinoma by acting as a competing endogenous RNA on microRNA-876 and thereby increasing specificity protein 1 expression
Xiaoming Liu, Baorong Zhang, Yue Jia, Ming Fu
Abstract
plays an oncogenic part in TSCC cells both in vitro and in vivo via sponging of miR-876 and thereby upregulating SP1, which could be regarded as a promising target for TSCC therapy.
Topics & Concepts
Gene knockdownBiologyDownregulation and upregulationCancer researchmicroRNALong non-coding RNACell biologyCell growthCellRNACompeting endogenous RNAMolecular biologyCell cultureGeneGeneticsCancer-related molecular mechanisms researchCircular RNAs in diseasesRNA modifications and cancer