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TREM2 promotes hippocampal neurogenesis through regulating microglial M2 polarization in APP/PS1 mice

Xiaoqian Peng, Hong-Song Guo, Xiao Zhang, Xiangyuan Wu, John Bosco Ruganzu, Songdi Wu, Mingtao Zhao, Lei Li, Yang Yang, Shengfeng Ji, Weina Yang, Pengyu Ren

2025Experimental Neurology10 citationsDOI

Topics & Concepts

TREM2MicrogliaNeurogenesisDownregulation and upregulationNeural stem cellBrain-derived neurotrophic factorHippocampal formationPI3K/AKT/mTOR pathwayCell biologyNeuroinflammationBiologyNeurotrophic factorsNeuroscienceImmunologyReceptorStem cellSignal transductionInflammationBiochemistryGeneNeuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanismsNeurological Disease Mechanisms and Treatments
TREM2 promotes hippocampal neurogenesis through regulating microglial M2 polarization in APP/PS1 mice | Litcius