Elevation of phospholipase C-β1 expression by amyloid-β facilitates calcium overload in neuronal cells
Jiyu Park, So Hee Kim, Yeong Jin Kim, Il Hwan Kim, Youngsoo Oh, Kyu Yeong Choi, Byeong C. Kim, Kun Ho Lee, Woo Keun Song
Abstract
oligomer-induced calcium overload in SH-SY5Y cells was alleviated by knockdown of PLCB1, indicating that PLCB1 plays an essential role in the neurotoxic process initiated by Aβ. The elevation of PLCB1 expression was confirmed in the brain tissues from the 5× familial AD (5×FAD) model mice. These findings suggest that PLCB1 may represent a potential therapeutic target for protecting neuronal cells against excitotoxicity in AD progression.
Topics & Concepts
NeurodegenerationCalcium in biologyExcitotoxicityCell biologyCalciumBiologyCalcium signalingIntracellularRyanodine receptorChemistryDownregulation and upregulationEndocrinologyInternal medicineBiochemistryReceptorMedicineGlutamate receptorDiseaseGeneAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchCholinesterase and Neurodegenerative Diseases