Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species
Kelly A. Fader, Ingrid D. Pardo, Ramesh C. Kovi, Christopher J. Somps, Helen Hong Wang, Vishal S. Vaidya, Shashi K. Ramaiah, Madhu P. Sirivelu
Abstract
vg/dose). Consistent with the unique positioning of DRGs outside the blood-brain barrier, NF-L in cerebrospinal fluid was only weakly associated with DRG findings. In summary, circulating NF-L is a promising biomarker of AAV-induced DRG toxicity in nonclinical species.
Topics & Concepts
BiomarkerToxicityNeurotoxicityMedicinePathologyNeurofilamentInfiltration (HVAC)PharmacologyBiologyInternal medicineImmunohistochemistryPhysicsThermodynamicsBiochemistryNerve injury and regenerationVirus-based gene therapy researchPeripheral Neuropathies and Disorders