An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy
Braxton L. Jamison, Matthew Lawrance, Chun Jing Wang, Hannah A. DeBerg, Lauren Ziegler, David M. Sansom, Marc A. Gavin, Lucy S. K. Walker, Daniel Campbell
Abstract
cells have enhanced functional properties and restrict cDC function, offering promise for targeted immunotherapy use in autoimmune disease.
Topics & Concepts
Cell biologyCTLA-4Dendritic cellImmunologyT cellRegulatory T cellChemistryBiologyImmune systemIL-2 receptorT-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Cell Function and Interaction