The role of sialidase Neu1 in respiratory diseases
Shiran Mei, Dingding Li, Aoyi Wang, Guoxue Zhu, Bingwen Zhou, Nian Li, Yi Qin, Yanliang Zhang, Shujun Jiang
Abstract
Neu1 is a sialidase enzyme that plays a crucial role in the regulation of glycosylation in a variety of cellular processes, including cellular signaling and inflammation. In recent years, numerous evidence has suggested that human NEU1 is also involved in the pathogenesis of various respiratory diseases, including lung infection, chronic obstructive pulmonary disease (COPD), asthma, and pulmonary fibrosis. This review paper aims to provide an overview of the current research on human NEU1 and respiratory diseases.
Topics & Concepts
SialidaseRespiratory systemMedicineImmunologyMicrobiologyBiologyInternal medicineNeuraminidaseVirusGlycosylation and Glycoproteins ResearchGalectins and Cancer BiologyEndoplasmic Reticulum Stress and Disease