A novel membrane-bound interleukin-2 promotes NK-92 cell persistence and anti-tumor activity
Qi Xiong, Hantao Zhang, Xuanle Ji, Yong Zhang, Gang Shi, Lei Dai, Fuyi Cheng, Huiling Wang, Jieyan Luo, Jia Xu, Yanhong Ji, Xiaolan Su, Weixiao Yang, Lin Zhang, Hongxin Deng
Abstract
, independent of exogenous IL-2, while mbIL-2-expressing NK-92 cells do not support bystander cell survival or proliferation. Additionally, mbIL-2 enhanced NK-92 cell-mediated antitumor activity by tuning the IL-2 receptor downstream signals and NK cell receptor repertoire expression. To conclude, our novel mbIL-2 improves NK-92 cell persistence and enhances NK-92 cell-mediated antitumor activity. NK-92 cells genetically modified to express the novel mbIL-2 with potential significance for clinical development.
Topics & Concepts
Interleukin 21Interleukin 12Lymphokine-activated killer cellJanus kinase 3Interleukin 15ImmunotherapyCellBiologyNK-92Cell biologyCytokineImmunologyCancer researchNatural killer cellReceptorT cellInterleukinCytotoxic T cellIn vitroImmune systemGeneticsBiochemistryImmune Cell Function and InteractionCAR-T cell therapy researchT-cell and B-cell Immunology