Network pharmacology and experimental investigation of <i>Rhizoma polygonati</i> extract targeted kinase with herbzyme activity for potent drug delivery
Yingqiu Xie, Chengling Mu, Bexultan Kazybay, Qing-lei Sun, Aidana Kutzhanova, Guldan Nazarbek, Na Xu, Lazzat Nurtay, Qian Wang, Amr Amin, Xugang Li
Abstract
. Thus the processed extract of RP-Mount Tai may play a dual role in the inhibition of cell proliferation signaling by both chemical component and nanoscale herbzyme of phosphatase activity to inhibit kinases including mTOR/AKT in potent drug delivery of kinase inhibitors.
Topics & Concepts
PI3K/AKT/mTOR pathwayKinaseProtein kinase BPharmacologyPhosphataseChemistrySignal transductionBiologyBiochemistryPhosphorylationPharmacological Effects of Natural CompoundsMedicinal Plants and Bioactive CompoundsBiochemical and Molecular Research