Aryl diazonium intermediates enable mild DNA-compatible C–C bond formation for medicinally relevant combinatorial library synthesis
Xianfeng Li, Juan Zhang, Changyang Liu, Jie Sun, Yangfeng Li, Yangfeng Li, Gong Zhang, Yizhou Li, Yizhou Li
Abstract
, hydroxamic acid), emphasizing the superiority of the aryl diazonium-based approach. Together with the convenient transformation into an aryl azide photo-crosslinker, aryl diazonium's DNA-compatible diversification synergistically demonstrated its competence to create medicinally relevant combinatorial libraries and investigate protein-ligand interactions in pharmaceutical research.
Topics & Concepts
ArylCombinatorial chemistrySubstrate (aquarium)Functional groupHalideChemistryOrthogonalityScope (computer science)Organic chemistryComputer scienceBiologyMathematicsProgramming languagePolymerAlkylGeometryEcologyChemical Synthesis and AnalysisClick Chemistry and ApplicationsSynthesis and Biological Evaluation