Ferroptosis promotes sonodynamic therapy: a platinum(<scp>ii</scp>)–indocyanine sonosensitizer
Yidan Lai, Nong Lu, Ai Ouyang, Qianling Zhang, Pingyu Zhang
Abstract
A novel platinum( ii )–cyanine complex showed a greater excellent sonodynamic therapeutic effect than photodynamic therapy in vivo . This work expands the biological applications of metal complexes from traditional photodynamic therapy to sonodynamic therapy.
Topics & Concepts
Sonodynamic therapyPhotodynamic therapyIn vivoChemistryCytotoxicityBioorthogonal chemistryGlutathioneCancer researchCancer cellSinglet oxygenReactive oxygen speciesInternalizationBiophysicsCancerBiochemistryCellIn vitroCombinatorial chemistryMedicineOxygenBiologyInternal medicineEnzymeBiotechnologyClick chemistryOrganic chemistryNanoplatforms for cancer theranosticsLanthanide and Transition Metal ComplexesNanoparticle-Based Drug Delivery