Targeting Smurf1 to block PDK1–Akt signaling in KRAS-mutated colorectal cancer
Zhiqiang Peng, Fang Wei, Bo Wu, Ming He, Shaohua Li, Jun Wei, Yang Hao, Lujia Jin, Mingqiu Liu, Xin Zhang, Yange Wei, Yingwei Ge, Yinghua Wei, Haili Qian, Yangjun Zhang, Junyi Jiang, Zhijie Chang, Yu Rao, Xueli Zhang, Chun‐Ping Cui, Lingqiang Zhang, Chun‐Ping Cui, Lingqiang Zhang
Topics & Concepts
KRASColorectal cancerProtein kinase BCancer researchSignal transductionPI3K/AKT/mTOR pathwayBlock (permutation group theory)ChemistryComputational biologyBiologyCancerCell biologyGeneticsGeometryMathematicsPI3K/AKT/mTOR signaling in cancerTGF-β signaling in diseasesMetabolism, Diabetes, and Cancer