DR-region of Na<sup>+</sup>/K<sup>+</sup>-ATPase is a target to ameliorate hepatic insulin resistance in obese diabetic mice
Hai‐Jian Sun, Lei Cao, Mengyuan Zhu, Zhiyuan Wu, Chenyou Shen, Xiao-Wei Nie, Jin‐Song Bian
Abstract
: Our findings suggest that NKAα1 is a physiological regulator of glucose homoeostasis and its DR-region is a novel target to treat hepatic insulin resistance.
Topics & Concepts
Insulin resistanceInternal medicineInsulinEndocrinologyATPaseDiabetes mellitusChemistryMedicineEnzymeBiochemistryPancreatic function and diabetesDiet, Metabolism, and DiseaseIon Transport and Channel Regulation