Isolation of circulating exosomes and identification of exosomal PD-L1 for predicting immunotherapy response
Junli Zhang, Yifan Zhu, Mengting Guan, Yingying Liu, Min Lv, Chongwei Zhang, Hongling Zhang, Zhenzhong Zhang
Abstract
assay could better distinguish exosomes derived from melanoma cells with different levels of PD-L1. Accurate measurement of exosomal PD-L1 could provide critical clinical information for cancer diagnosis and personalized immunotherapy of cancer.
Topics & Concepts
MicrovesiclesExosomeCD63ImmunotherapyCD81VesicleExtracellular vesiclesMicrovesicleBiologyCancer researchCell biologyChemistryImmune systemImmunologymicroRNABiochemistryMembraneHepatitis C virusGeneVirusExtracellular vesicles in diseaseThermal properties of materialsNanopore and Nanochannel Transport Studies