Chemical tools to track and perturb the expression of sialic acid and fucose monosaccharides
Emiel Rossing, Johan F. A. Pijnenborg, Thomas J. Boltje
Abstract
The biosynthesis of glycans is a highly conserved biological process and found in all domains of life. The expression of cell surface glycans is increasingly recognized as a target for therapeutic intervention given the role of glycans in major pathologies such as cancer and microbial infection. Herein, we summarize our contributions to the development of unnatural monosaccharide derivatives to infiltrate and alter the expression of both mammalian and bacterial glycans and their therapeutic application.
Topics & Concepts
MonosaccharideSialic acidFucoseChemistryBiochemistryTrack (disk drive)GalactoseComputer scienceOperating systemGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and SynthesisMicrobial Metabolites in Food Biotechnology