Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide25-35-induced memory impairment in mice
Mitsuru Tanaka, Hayato Kiyohara, Atsuko Yoshino, Akihiro Nakano, Fuyuko Takata, Shinya Dohgu, Yasufumi Kataoka, Toshiro Matsui
Abstract
-induced mice were performed to provide in vivo evidence on the potential of the blood-brain barrier transportable soy dipeptide, Tyr-Pro, in combating memory impairment. We demonstrated for the first time that oral administration of Tyr-Pro (100 mg/kg, twice a day) in mice for 16 days significantly improved impaired memory by spontaneous alternation and shortened step-through latency in amyloid β-induced mice.
Topics & Concepts
DipeptideMemory impairmentIn vivoAmyloid (mycology)PeptideAmyloid precursor proteinMedicineBlood–brain barrierChemistryPharmacologyInternal medicineNeuroscienceEndocrinologyPsychologyAlzheimer's diseaseBiochemistryBiologyPathologyCentral nervous systemCognitionDiseaseBiotechnologyAlzheimer's disease research and treatmentsBiochemical effects in animalsPhytoestrogen effects and research