Electrochemical cascade migratory <i>versus ortho</i> -cyclization of 2-alkynylbenzenesulfonamides
Zhaojiang Shi, Shicheng Dong, Ting Liu, Weizhen Wang, Nan Li, Yaofeng Yuan, Jun Zhu, Ke‐Yin Ye
Abstract
-cyclization cyclization selectively. It is found that the incorporation of an extra 2-methyl substituent biases the selective migration of the acyl- over vinyl-linker of the key spirocyclic cation intermediate and thus serves as an enabling handle to achieve the synthetically interesting yet under-investigated cascade migratory cyclization of spirocyclic cations.
Topics & Concepts
CascadeElectrochemistryChemistryChromatographyElectrodePhysical chemistryRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods