TCR-induced FOXP3 expression by CD8+ T cells impairs their anti-tumor activity
Teresa Lozano, Enrique Conde, Celia Martín-Otal, Flor Navarro, Aritz Lasarte-Cía, Rabab Nasrallah, Diego Alignani, Marta Gorraiz, Pablo Sarobe, Juan P. Romero, Amaia Vilas‐Zornoza, Rahul Roychoudhuri, Sandra Hervás‐Stubbs, Noëlia Casares, Juan José Lasarte
Topics & Concepts
FOXP3Cytotoxic T cellCD8T cellIL-2 receptorBiologyInterleukin 21Tumor microenvironmentCancer researchT-cell receptorAdoptive cell transferCell biologyImmunologyChemistryImmune systemIn vitroBiochemistryCAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell Immunology